For movies featuring substance abuse, see List of drug films. Thin-film drug delivery has emerged as an advanced alternative to the traditional tablets, capsules and liquids often associated with prescription and OTC medications. Different buccal delivery products have pediatric drug formulations pdf marketed or are proposed for certain diseases like trigeminal neuralgia, Meniere’s disease, diabetes, and addiction.
Formulation of oral drug strips involves the application of both aesthetic and performance characteristics such as strip-forming polymers, plasticizers, active pharmaceutical ingredient, sweetening agents, saliva stimulating agent, flavoring agents, coloring agents, stabilizing and thickening agents. The polymer employed should be non-toxic, non-irritant and devoid of leachable impurities. It should have good wetting and spreadability property. The polymer should exhibit sufficient peel, shear and tensile strengths. The polymer should be readily available and should not be very expensive. Film obtained should be tough enough so that there won’t be any damage while handling or during transportation.
Plasticizer is a vital ingredient of the OS formulation. It helps to improve the flexibility of the strip and reduces the brittleness of the strip. Plasticizer significantly improves the strip properties by reducing the glass transition temperature of the polymer. Since the size of the dosage form has limitation, high-dose molecules are difficult to be incorporated in OS.
An important aspect of thin film drug technology is its taste and color. The sweet taste in formulation is more important in case of pediatric population. Natural sweeteners as well as artificial sweeteners are used to improve the flavor of the mouth dissolving formulations for the flavors changes from individual to individual. Pigments such as titanium dioxide is incorporated for coloring. The stabilizing and thickening agents are employed to improve the viscosity and consistency of dispersion or solution of the strip preparation solution or suspension before casting. Drug content uniformity is a requirement for all dosage forms, particularly those containing low dose highly potent drugs.
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To uniquely meet this requirement, thin film formulations contain uniform dispersions of drug throughout the whole manufacturing process. Montelukast indicated for the treatment of asthma and allergy, is being developed for use as a film by Monosol Rx. Midatech, a company specializing in nanotechnology, is partnering with Monosol Rx to create a film-based insulin. 5th Annual European Life Science CEP Forum for Partnering and Investing. Rizatriptan indicated for the treatment of migraine, is being developed for use as a film by Monsoon Rx and Zim Laboratories Ltd. Monosol Rx is also developing a testosterone film-based therapeutic for the treatment of male hypogonadism. The product is currently in phase 1.